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Medication for Diabetes, Obesity May Help Treat Cocaine Addiction

Cocaine is a stimulant that increases the availability of the neurotransmitter dopamine in the brain, causing the heart to beat faster and blood vessels to constrict. As with all drugs, the risk of relapse is high, even after long periods of abstinence. Its repeated use can develop tolerance, implying that an addict cannot simply stop using the drug by willpower alone. At the same time, it would require higher doses and/or more frequent use of cocaine to experience the same level of pleasure experienced during initial use.

Cocaine dependence is a highly prevalent public health problem in the United States. Therefore, the development of an effective drug to treat it becomes a priority. Now, researchers from the University of Pennsylvania School of Nursing and the Perelman School of Medicine have shown that an FDA-approved drug currently used to treat obesity and type 2 diabetes may also be effective in treating drug addiction. the cocaine.

Published in the journal Neuropsychopharmacology In February 2016, the study claims that the drug called Byetta, derived from a natural hormone called glucagon-like peptide-1, or GLP-1, may be an effective treatment for cocaine addicts. The researchers conducted a study in rats, demonstrating that when GLP-1 receptors were activated, the tiny animals self-administered less cocaine.

“We’re looking at what activation of GLP-1 receptors in the VTA does to cocaine self-administration by the animal,” says Heath Schmidt, lead author of the study. “We were able to show a nice reduction in cocaine self-administration.”

Although it has not yet been tested in humans, if this research continues to progress successfully, those working to treat cocaine addiction may soon have another treatment option.

What is NAD?

In light of current cocaine overdoses, a survey by the Mental Health Services Administration (SAMHSA) revealed that approximately 24.6 million Americans age 12 and older—9.4 percent of the population—had used illegal drugs in a month before the 2013 survey.

To manage the pain that the detox process can create, experts have developed a physically assisted detox treatment that includes neurotransmitter restoration (NTR) and nicotinamide adenine dinucleotide (NAD) therapies as two components. Physically assisted detoxification therapy is highly recommended for addiction treatments.

Through intravenous and oral supplementation, NTR helps replenish amino acids, vitamins and minerals, providing patients with faster and more thorough restoration of nutritional function and neurotransmitters. The process usually starts at the same time as regular detox and takes about 10 days to complete. Patients are monitored by doctors in a typical detox environment. On the other hand, NAD therapy is used to improve mental clarity, alertness, concentration, and memory in patients with addiction.

How does NAD/NTR therapy work?

NAD/NTR therapy greatly accelerates the natural healing process by allowing the necessary building blocks for the brain to produce new neurotransmitters and receptors. Administered to patients via intravenous drip over a period of 10 to 14 days, NAD saturates cells to restore cellular energy and functionality caused by NAD deficiency. NAD is the first step in recovery from drug and alcohol addiction and has been reported to be effective in improving a wide variety of chronic health conditions.

IV NAD therapy offers the following benefits to the body:

  • It provides the essential minerals needed to activate brain and heart cells, as well as other body organs.

  • It enhances the production of serotonin, dopamine and norepinephrine, which improves mood in depressed situations.

  • Improves mental stability and performance.

  • It strengthens the immune system and promotes overall health.

In rehab, patients are offered appropriate care and treatment and encouraged to address impairments in their social and work lives. Life skills learned in rehabs allow patients to have a smooth transition to a more independent lifestyle. It is not easy to fight the misfortune of substance addiction, but with proper treatment and care a person can reclaim their life and live it freely.

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