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Which Remedies For Baldness Work?

WHICH TREATMENT FOR BALDNESS WORKS?

With every baldness drug, I’ve been divided into two categories: “drugs” and “naturals.” Both treatments for baldness are said to work to some extent. Medicines (creams and pills) have had various clinical trials on them, but on the downside they are occasionally susceptible to unwanted side effects. Natural treatments for baldness most often had no clinical trials attached, just word of mouth recommendations, but usually have fewer side effects (at least less unwanted). If you’re not sure which type to try, it’s possible to try both (but ask a doctor for advice before doing so).

ALLOPATHIC ITEMS FOR BALDNESS

Before starting with any allopathic medicines for baldness, I need to explain the current thinking in the science behind the causes of hair loss so that the mechanism and effectiveness of the medicines can be easily understood.

Men convert excess testosterone into a more potent form called DHT by the enzyme 5a reductase. DHT is particularly active on hair follicle receptors, easily sticking to them and restricting blood flow to the hair. This causes the hair to thin and shorten creating the “peach fuzz”. Apparently there is a higher amount of this enzyme in the scalp of men who are prone to male pattern baldness.[1]

Women, however, have an excess of the aromatase enzyme that converts their testosterone into a form of active estrogen called estradiol. The theory is that after menopause, their natural estrogen levels drop allowing testosterone to convert to DHT, which makes them more susceptible to postmenopausal hair loss. However, this does not explain why postmenopausal men lose their hair as they age and their testosterone levels decline.[1]

Well, that’s the theory, so now let’s look at each baldness drug in turn and determine its effectiveness and availability as of July 2006. Below is a list of each baldness drug:

Rogaine (Minoxidol)

Propecia (Finasteride)

ROGAINE

Mechanism – unclear. It seems to open up the availability of potassium to the hair.

Effectiveness – average hair growth per cm2 was 18.5% after 48 weeks. 1 to 3 months after stopping, hair condition returns to pre-treatment levels.

Side Effects – Dizziness has been reported. Local irritation, pruritus, dryness, and erythema may occur with the use of topical minoxidil, likely caused by the composition of the alcohol and propylene glycol vehicle.[2]

Availability – over the counter.

Cost – $10 to $15 per bottle (one month).

PROPERTY

Mechanism – inhibits the 5a reductase enzyme responsible for the production of DHT.

Effectiveness – A third study of 326 men with mild to moderate frontal hair loss found that after 1 year, men treated with finasteride had a statistically significantly higher number of hairs on the frontal scalp. About 50% of the men who received treatment and 30% of those who received a placebo believed that the appearance of their hair had improved. No hair regrowth was reported in elderly men receiving 5 mg of finasteride.

Side Effects – Decreased libido, erectile dysfunction, or decreased ejaculate volume have been reported in less than 2% of patients, which is actually between 0.5% and 1% compared to placebo.[2]

Availability – was by prescription only. The general release is now available.

Cost – $69.95 for 3 months

NATURAL ITEMS FOR BALDNESS

Most natural baldness treatments also work by blocking DHT, either by blocking the enzyme or by blocking the hair follicle receptor, or by providing the nutrient for the hair follicle receptor that DHT blocks. There is also an alternative interpretation of the “DHT only causes hair loss” theory. Some believe that too much estrogen-like active substances as well as too much DHT and not enough free testosterone in the body are responsible for prostate cancer and hair loss.[3]

This sounds contradictory to the allopathic argument, and when it comes to estrogen it is. Some naturopaths say it’s all about what blocks the hair follicle receptors. It is these protein receptors that attract nutrients to the hair. DHT and estrogen-like pollutants block the receptor.[3] Apparently, certain bacteria that thrive in fat produce estrogen-like substances[4]and there is an excess of the aromatase enzyme (which converts testosterone to estrogen) present in the fat cells of obese and balding men. Aging, a high-fat diet, and lack of exercise can create too much estrogen and too little testosterone. Even if testosterone is at normal levels, active estrogen levels may be too high.[3] Although this does not explain why women with high estrogen levels do not experience male pattern baldness.

Here is a list of each baldness remedy and nutrients:

Beta Sistosterol (from the herb: Saw Palmetol)

Chrysin (from the herb: Passionflower)

Vitamin D

Vitamin B12

Biotin (vitamin B7)

Iron and L-lysine (for women)

Folligen (copper peptide)

Soy

Rooibos tea

BETA SISTOSTEROL

Mechanism – blocks DHT from androgen receptor sites located in hair follicles.

Efficacy – not tested. Mixed reviews from people on health forums.

Side Effects – None, but the side effects of Saw Palmetol herb can be male breast enlargement.[2]

Availability – over the counter.

Cost – 90 400mg Capsules $7.95.

GOLD

Mechanism – increases free testosterone by inhibiting conversion to estradiol.

Efficacy – shown to be effective in stopping aromatase in the petridish, but not in the body. It is not known if it helps with hair loss.[5] It is not a proven cure for baldness.

Side effects – none.

Availability – over the counter.

Cost – MRM, Chrysin 500, 30 Caps. $14.99.

VITAMIN D

Mechanism – binds to the many vitamin D receptors on the scalp and hair follicle.

Efficacy – shown to dramatically stimulate hair follicle growth in “naked” mice.[6]

Side effects – none, unless taken over 50 micrograms per day.

Availability – over the counter.

Cost – 400iu (10 micrograms) 60 capsules $4.99.

VITAMIN B12

Mechanism – deficiency causes hair loss.[7]

Effectiveness – 40% of Americans are ineffective. It has not been shown to treat hair loss if taken.[8]

Side Effects – None, unless taken over 100 mcg daily.

Availability – over the counter.

Cost – 1000 mcg, $7.99 tablets.

BIOTIN (VITAMIN B7)

Mechanism – increases blood flow to the hair follicle.[9]

Effectiveness – can promote hair growth in high doses, although it is not a proven cure for baldness.

Side effects – none.

Availability – over the counter.

Cost – 300mcg tablets $2.99.

IRON AND L-LYSINE (for women)

Mechanism – deficiencies in both of these nutrients have been associated with hair loss in women.[10] Interacts with zinc and copper.[11]

Effectiveness – proven effective baldness treatment for women with hair loss.[10]

Side effects – none unless more than 250 mg daily (iron) is taken.

Availability – over the counter.

Cost – 100 tablets $7.29

FOLLIGEN (copper peptide)

Mechanism – the most effective inhibitor of the production of both types of 5a reductase enzyme.[12]

Effectiveness – low levels of copper and zinc enzymes caused hair loss in mice.[13] A topical copper peptide solution produced almost perfect hair regeneration in 6 months in a woman with 10% of her hair to begin with.[14] There are no studies on the baldness treatment Folligen itself, but some reports of success from women on forums.

Side effects – none.

Availability – over the counter.

Cost – 2 oz tube, $21.95. 2 months.

SOY

Mechanism – promotes the production of the good inactive estrogen. Blocks receptor sites for active estrogen and inhibits reductase 5a.[3]

Effectiveness – proven to inhibit the enzyme 5a reductase.[15]

Side effects – none.

Availability – over the counter. Nutrient, not medicine for baldness.

Cost – ?

ROIBO TEA

Mechanism – unclear.

Effectiveness – in a 10% lotion called herbasol, 89% had increased speed of hair growth. 45% saw an increase in hair growth. 78% reported no further hair loss.[2]

Side effects – none.

Availability – over the counter. A food substance, not a medicine for baldness except for the above.

Cost – ?

I would personally recommend trying Beta Sistosterol with a strong multivitamin and mineral supplement combined with Folligen solution as a good baldness treatment.

————————————————– ——————————

[1] Have scientists accidentally discovered the answer to hair loss?

http://www.emaxhealth.com/65/6131.html

[2] Treatments for hair loss.

[http://www.hairlosstalk.com/download/sawaya1.pdf]

[3] Get young and lean

[http://www.growyoungandslim.com/articles/Mens_Health_102a.pdf]

[4] Health loss education

http://www.stuff4beauty.com/page/hairlosseducation.htm

[5] Chrysin: Is it an effective aromatase inhibitor?

http://www.vrp.com/art/1208.asp

[6] Vitamin D3 analogs stimulate hair growth in nude mice.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12399436&query_hl=41

[7] Diet and Nutrition – vitamin B12.

http://www.internethealthlibrary.com/DietandNutrition/VitaminB12.htm

[8] Do you need B-12?

http://thyroid.about.com/cs/newsinfo/l/blb12anemia.htm?terms=vitamin+B12+and+Tufts+

[9] Biotin and hair growth

http://www.add-hair.com/Biotin-hair-loss.htm

[10] Dietary factors and hair loss.

http://www.blackwell-synergy.com/links/doi/10.1046/j.1365-2230.2002.01076.x/abs/

[11] Interaction of iron, zinc and copper in the body of animals and humans

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2700243&dopt=Abstract

[12] Folligen

http://www.folligen.com/

[13] Age-related loss of cochlear hair cells is enhanced in mice lacking copper/zinc superoxide dismutase

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10466888&dopt=Abstract

[14] Have scientists accidentally discovered the answer to hair loss?

http://www.emaxhealth.com/65/6131.html

[15] Regulation of male sex hormone levels by soy isoflavones in rats

http://www.leaonline.com/doi/abs/10.1207/S15327914NC422_9;jsessionid=nFFp1FovOhX-OhcS3V?cookieSet=1&journalCode=nc

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