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Significance of Pharmacokinetic

Pharmacokinetics tells various ways (such as intravenous injection, intravenous injection, oral administration, etc.) by which drugs pass into the body for absorption, distribution, metabolism and excretion, which is ADME The development and application of pharmacokinetics in The last years have shown her a special and important position in the field of pharmaceuticals that she held. First of all, pharmacokinetics, as a means of dealing with the mathematical analysis of the dynamic processes of scientific medicine in the body, has an important theoretical value. It is an important part of “mathematical pharmacy”. Its basic analysis method has penetrated biological pharmacy, clinical pharmacology, drug therapy, clinical pharmacology, molecular pharmacology, biochemistry analytical chemistry, pharmacology and toxicology, pharmaceutical and many other fields of science, being the largest and main foundation of these subjects. promoting their dynamic development. At the same time, pharmacokinetics has a very wide range of practical importance.

Its development will be existing in drug evaluation, improvement of pharmaceutical dosage form, active design of new drugs, provision of effective, rapid, effective, low toxic and side effect drugs, and guiding the clinical rational use of drugs. Through the study of pharmacokinetics, it plays an important role in the effective drug concentration in the blood of clinical treatment, the optimal dose, the dosing cycle, the calculation of the loading dose, and whether continuous medication would occur in vivo accumulation. In a word, pharmacokinetics has become a useful new tool, widely used in the pharmaceutical field and various industries. A United Nations WHO technical report emphasizes that: “For the evaluation of drug efficacy and toxicity, pharmacokinetics, not only at the stage of preclinical pharmacological study, but also at all stages of drug discovery shows significant value.”

Importance in the new drug development process: In the development of a new drug, we often hope to achieve the desired requirements by transforming the chemical structure, but it also causes the drug itself to change. Therefore, in the design of new compounds, pharmacokinetics can play a guiding role in analyzing the effect of drug structure on parameters and discovering which genes can alter drug absorption. And with the rules we discover, we can design new compounds.

Significance in the study of Chinese herbal medicine: In recent years, Chinese herbal medicine research has achieved great development, such as Silybum marianum seed extract based on pharmacokinetics.

Importance in Pharmacological Research: As we know, pharmacology is to study medicine and the interaction of the body of life. It discovers the effects of drugs on the body on the one hand, and also studies the effect of the body on drugs on the other. Thus, pharmacology is often divided into pharmacodynamics and pharmacokinetics.

Importance in clinical drug use: Pharmacokinetics and clinical pharmacy are combined, producing (clinical pharmacokinetics), in order to carry out clinically individualized drug administration, including dose, dosing interval, route of administration, dosage form in the choice of content.

Importance in the fields of pharmaceuticals, biopharmaceuticals, etc. In 1968 Australia produced phenytoin sodium tablets which have good results all the time. Later, some people used lactose instead of CaSO4 in the recipe and a case of poisoning occurred.

In summary, pharmacokinetics has become a useful new tool in a wide range of applications. The ways of finding new drugs are gradually transferred from experience to a more logical form, in order to produce new drugs, good drugs and conquer all kinds of diseases, illnesses, and finally create a new state of medical and healthy enterprise.

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